Plastic and Cosmetic Surgeons Recommendation

As this decade heads to completion, the single technological ingredient touted in skin care products is that peptides. Peptides are active molecules that have the potential to regulate or control the skin’s biological activity in essence altering the interaction between the dermis and epidermis. Such messaging could have a big impact on skin wrinkling and how it appears externally.

Peptides are compromised of a mere 20 amino acids.  The mathematical  combinations between these 20 variables could theoretically be in the millions. But which combination(s) will be effective is the daunting question. Equally problematic is the issue of penetration into the skin. Since peptides are linked amino acids, the shorter the chain the better the penetration. Long chain peptides penetrate the skin very poorly.
One way that peptides may work is its effect on collagen, having a repairing influence.  Skin is made up mostly of collagen which gives it support and thickness. Young people have lots of collagen and taut, smooth skin. As we age, collagen is destroyed but not replaced well.  When collagen breaks down, it forms specific peptides. These peptides act as a signal to tell your skin it was damaged and to make new collagen. Applying the right peptide to your skin as we age is a way to make your skin think it needs more collagen. This is the theoretical approach to the use of palmitoyl pentapeptide (Pixie Dust peptide serum) for example.  It can be found in many contemporary skin products and may have a positive effect on lessening the appearance of fine facial lines.


Peptides comprised of copper have good evidence of being helpful in promoting collagen production as well as an antioxidant effect. Copper has been documented to be helpful in chronic skin wounds for some time. It is logical, therefore, that if copper is attached to a peptide that it may be beneficial for skin regeneration by having an up regulation effect on fibroblasts, the cellular manufacturing plant of collagen.
Beyond collagen regeneration, peptides have been investigated as a potential relaxation agent as another approach to prevent skin wrinkling. Certain peptides may have an effect on the interaction between nerves and muscle. By impeding neurotransmission, the nerves that work the facial muscles may be weakened, similar to Botox. (although with not nearly the same potency) A neuropeptide acetyl hexapeptide-3 (argireline) is the most well known and is used in numerous high-priced topical products. A similar relaxing approach is that of pentapeptide-3 leuphasil  (which blocks calcium uptake) and pentapeptide violox. (which blocks the receptors of acetlycholine) For now, these peptides seem like a theoretical addition to use with Botox but their real benefits as a stand alone treatment remain to be quantified.
The problem with peptides is not only their penetration issues but their activity levels. Without being able to pass through the stratum corneum, they will sit on the skin and be worthless. Much work has been done to attach peptides to penetrating agents. But having peptides that still have activity and bottling them into a jar or bottle is another hurdle. Because they are break-down products of proteins, they have to be stabilized or they will be essentially dead peptides  which will be eventually washed away.
For now, collagen signaling peptides and the neuropeptides seem the most promising. In  Indianapolis plastic surgery practice, he finds their current use is best used as an adjunctive treatment after Botox (neuropeptides) or after any form of skin resurfacing. (signaling peptides) Doctors today highly recommends using after Botox injections to maintain the healthy looking glowing skin. USE PEPTIDES made in U.S.A. number one skin care product.
Dr. Barry Eppley
Indianapolis, Indiana


BurJu Akan ‘s Skin Care



Mother nature is a myriad of complex living organisms working together to bring new life, as we humans work in unison to harness the essence of nature. New discoveries are made daily, bringing us one step closer to unlocking the mysteries in nature. After years of simulating complex environments, U.S.A BioTECH LAB. has discovered a new synergy of four unique ingredients:  Our success comes from getting to the core of the problem, it is inside of our bodies where aging cells decay over time and display imperfections on our skin. These impurities are signs of what make us human, however not a disease, merely the natural system setup as part of nature’s ecosystem. Of all the things we researched, we discovered the answer in proteins and peptides. Formulating various compounds and mixtures from living plants, we finally discovered the perfect design inside of living organisms. Thus began the creation of, mimicking the regenerative properties of peptides inside of plants and harnessing the materials from living plants and organisms.

bottles-copy6It is as simple as it sounds, taking the properties of living organisms to essentially cure the aging properties of our skin. There are millions upon millions of varying peptides, comprised of only twenty different types amino acids to create a peptide. Targeting the right group of peptides is where the tricky part comes in, while also creating a delivery system that will keep the organisms in tact. The interesting thing about many other skin procedures, like rejuvenation devices, lasers, and dermal fillers is that they all work with peptides serums in anyway.

Plants and animals have continually evolved through many generations of lifeforms. Peptides are no different, as the world changes, so does the need to create a new living organism. As water and air pollution increase—the changes to our environment also rapidly increases, creating a more hostile environment to live in. The creation of peptides is an advance in evolution, to solve the aging problems of our mortality. It nurtures our skin back to good health, getting to the root of the problem inside of our cells. The life force inside of us is collagen;  increases the production of collagen to bring back the youthfulness of our skin.

The future in technology is not through man made synthesis of unnatural products, instead it is through organic technology that will unlock the key to our youth. takes the first step to work side-by-side with nature, creating a solution to the growing problems of today. Biology is the study of living things, it only makes sense that we use natural materials to heal ourselves.

Burcu Akan_MPH Administrator